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Title:

Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Konzack, Anja; Jakupovic, Mirza; Kubaichuk, Kateryna; Görlach, Agnes; Dombrowski, Frank; Miinalainen, Ilkka; Sormunen, Raija; Kietzmann, Thomas
Abstract:
One of the cancer hallmarks is mitochondrial dysfunction associated with oxidative stress. Among the first line of defense against oxidative stress is the dismutation of superoxide radicals, which in the mitochondria is carried out by manganese superoxide dismutase (MnSOD). Accordingly, carcinogenesis would be associated with a dysregulation in MnSOD expression. However, the association studies available so far are conflicting, and no direct proof concerning the role of MnSOD as a tumor promoter...     »
Journal title abbreviation:
Antioxid Redox Signal
Year:
2015
Journal volume:
23
Journal issue:
14
Pages contribution:
1059-75
Language:
eng
Fulltext / DOI:
doi:10.1089/ars.2015.6318
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26422659
Print-ISSN:
1523-0864
TUM Institution:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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