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Titel:

Superoxide-Generating Nox5? Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Shigemura, Tomonari; Shiohara, Masaaki; Kato, Masayoshi; Furuta, Shuichi; Kaneda, Kazuko; Morishita, Kazuhiro; Hasegawa, Hiroo; Fujii, Masahiro; Görlach, Agnes; Koike, Kenichi; Kamata, Tohru
Abstract:
Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and transforms T cells in vitro. To our knowledge, the functional role of reactive oxygen species (ROS)-generating NADPH oxidase 5 (Nox5) in HTLV-1 transformation remains undefined. Here, we found that Nox5? expression was upregulated in 88% of 17 ATL patient samples but not in normal peripheral blood T cells. Upregulation of the Nox5? variant was transcriptionally sustained by the constitutive Janus famil...     »
Zeitschriftentitel:
J Virol
Jahr:
2015
Band / Volume:
89
Heft / Issue:
17
Seitenangaben Beitrag:
9080-9
Sprache:
eng
Volltext / DOI:
doi:10.1128/JVI.00983-15
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26109726
Print-ISSN:
0022-538X
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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