Circulating tumor cells versus objective response assessment predicting survival in metastatic castration-resistant prostate cancer patients treated with docetaxel chemotherapy.

Thalgott, M; Heck, M M; Eiber, M; Souvatzoglou, M; Hatzichristodoulou, G; Kehl, V; Krause, B J; Rack, B; Retz, M; Gschwend, J E; Andergassen, U; Nawroth, R

doi:10.1007/s00432-015-1936-z

journal article

Title:: Circulating tumor cells versus objective response assessment predicting survival in metastatic castration-resistant prostate cancer patients treated with docetaxel chemotherapy.
Document type:: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):: Thalgott, M; Heck, M M; Eiber, M; Souvatzoglou, M; Hatzichristodoulou, G; Kehl, V; Krause, B J; Rack, B; Retz, M; Gschwend, J E; Andergassen, U; Nawroth, R
Abstract:: Circulating tumor cell (CTC) counts might display a superior prognostic value for overall survival (OS) compared to objective response criteria (OR) in metastatic castration-resistant prostate cancer (mCRPC) patients.CTCs were detected using the CellSearch(TM) System out of 122 samples during docetaxel chemotherapy (75 mg/m(2)) at baseline (q0) and after 1 (q1), 4 (q4) and 10 (q10) cycles, in mCRPC patients (n = 33). OR was evaluated by morphologic RECIST and clinical criteria after 4 (q4) and 10 (q10) cycles.For OS, analyses revealed a significant prognostic value for categorical (<5 vs. >=5) CTC counts (q0, p = 0.005; q1, p = 0.001; q4, p < 0.001; q10, p = 0.002), RECIST (q4, p < 0.001; q10, p = 0.02) and clinical criteria (q4, p < 0.001; q10, p = 0.02). Concordance of CTC counts with OR revealed a sensitivity of 83.3-87.5 % and a specificity of 68.0-76.5 % with complementary discriminatory power for OS. Comparing CTC counts with concomitant OR at q4 in multivariate analyses, an independent prognostic value for OS was found for CTC counts (HR 3.3; p = 0.02) similar to clinical (HR 4.9; p = 0.02) and radiologic response (HR 3.4; p = 0.051). Comparing the predictive value for death, early post-treatment CTC counts at q1 demonstrated significant accuracy with an area under the curve of 79.5 % (p = 0.004) similar to CTC counts at q4 (76.7 %; p = 0.009). Radiologic and clinical response at q4 displayed accuracy similar to early CTC counts at q1 (72.2 %; p = 0.03 and 75.0 %; p = 0.02) despite low sensitivities.CTC counts appear to be an earlier and more sensitive predictor for survival and treatment response than current OR approaches and may provide complementary information toward individualized treatment strategies.
Journal title abbreviation:: J Cancer Res Clin Oncol
Year:: 2015
Journal volume:: 141
Journal issue:: 8
Pages contribution:: 1457-64
Language:: eng
Fulltext / DOI:: doi:10.1007/s00432-015-1936-z
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/25708944
Print-ISSN:: 0171-5216
TUM Institution:: Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Nuklearmedizin; Urologische Klinik und Poliklinik
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