Elevated serum 25(OH)-vitamin D levels are negatively correlated with molar-incisor hypomineralization.

Kühnisch, J; Thiering, E; Kratzsch, J; Heinrich-Weltzien, R; Hickel, R; Heinrich, J; GINIplus study group; LISAplus study group; Wichmann, H E; Heinrich, J; Sausenthaler, S; Zutavern, A; Chen, C-M; Schnappinger, M; Rzehak, P; Berdel, D; von Berg, A; Beckmann, C; Groß, I; Koletzko, S; Reinhardt, D; Krauss-Etschmann, S; Bauer, C P; Brockow, I; Grübl, A; Hoffmann, U; Krämer, U; Link, E; Cramer, C; Behrendt, H; Heinrich, J; Wichmann, H E; Sausenthaler, S; Chen, C M; Schnappinger, M; Borte, M; Diez, U; von Berg, A; Beckmann, C; Groß, I; Schaaf, B; Lehmann, I; Bauer, M; Gräbsch, C; Röder, S; Schilde, M; Herbarth, O; Dick, C; Magnus, J; Krämer, U; Link, E; Cramer, C; Bauer, C P; Hoffmann, U; Behrendt, H; Grosch, J; Martin, F     «

Kühnisch, J; Thiering, E; Kratzsch, J; Heinrich-Weltzien, R; Hickel, R; Heinrich, J; GINIplus study group; LISAplus study group; Wichmann, H E; Heinrich, J; Sausenthaler, S; Zutavern, A; Chen, C-M; Schnappinger, M; Rzehak, P; Berdel, D; von Berg, A; Beckmann, C; Groß, I; Koletzko, S; Reinhardt, D; Krauss-Etschmann, S; Bauer, C P; Brockow, I; Grübl, A; Hoffmann, U; Krämer, U; Link, E; Cramer, C; Behrendt, H; Heinrich, J; Wichmann, H E; Sausenthaler, S; Chen, C M; Schnappinger, M; Borte, M; Diez,...     »

To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-up of the Munich GINIplus and LISAplus birth cohorts. The dental examination included the diagnosis of MIH and recording of (non-)cavitated caries lesions in primary and permanent teeth. Serum 25(OH)D concentrations were taken from blood samples of the 10-year investigation and measured with a fully automated, modular system. Different logistic regression and Poisson hurdle models were calculated. MIH was diagnosed in 13.6% of the study population. Approximately 16.4% of the children demonstrated caries-related defects (D3-4MFS> 0). The mean season-adjusted concentration of 25(OH)D was 75.8 nmol/l (standard deviation 22.0 nmol/l). After adjusting for sex, age, body mass index, parental education, equivalent income, and television/personal computer (TV/PC) viewing hours, a 10 nmol/l increase in serum 25(OH)D concentrations was significantly associated with a lower odds ratio of having MIH (OR = 0.89; P = 0.006). Furthermore, higher 25(OH)D values were associated with a lower number of caries-affected permanent teeth. It is concluded that elevated serum 25(OH)D concentrations were associated with better dental health parameters.     «

To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-up of the Munich GINIplus and LISAplus birth cohorts. The dental examination included the diagnosis of MIH and recording of (non-)cavitated caries lesions in primary and permanent t...     »