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Titel:

Polyubiquitination of lysine-48 is an essential but indirect signal for MHC class I antigen processing.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Fiebiger, Benjamin M; Pfister, Heike; Behrends, Uta; Mautner, Josef
Abstract:
Peptides presented on major histocompatibility complex (MHC) class I molecules are generated via cytosolic proteolysis. However, the nature of the endogenous peptide precursors and the intracellular processing steps preceding protein degradation remain poorly defined. Here, we assessed whether ubiquitination is an essential signal for proteasomal cleavage of antigen substrates in human cells. Conversion into antigenic peptides occurred in the absence of any detectable N-terminal ubiquitination o...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2015
Band / Volume:
45
Heft / Issue:
3
Seitenangaben Beitrag:
716-27
Sprache:
eng
Volltext / DOI:
doi:10.1002/eji.201444830
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25500897
Print-ISSN:
0014-2980
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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