Benutzer: Gast  Login
Titel:

Regulatory T-cell impairment in cystic fibrosis patients with chronic pseudomonas infection.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Hector, Andreas; Schäfer, Heike; Pöschel, Simone; Fischer, Alexandra; Fritzsching, Benedikt; Ralhan, Anjali; Carevic, Melanie; Öz, Hasan; Zundel, Sabine; Hogardt, Michael; Bakele, Martina; Rieber, Nikolaus; Riethmueller, Joachim; Graepler-Mainka, Ute; Stahl, Mirjam; Bender, Annika; Frick, Julia-Stefanie; Mall, Marcus; Hartl, Dominik
Abstract:
Patients with cystic fibrosis (CF) lung disease have chronic airway inflammation driven by disrupted balance of T-cell (Th17 and Th2) responses. Regulatory T cells (Tregs) dampen T-cell activation, but their role in CF is incompletely understood.To characterize numbers, function, and clinical impact of Tregs in CF lung disease.Tregs were quantified in peripheral blood and airway samples from patients with CF and from lung disease control patients without CF and healthy control subjects. The role...     »
Zeitschriftentitel:
Am J Respir Crit Care Med
Jahr:
2015
Band / Volume:
191
Heft / Issue:
8
Seitenangaben Beitrag:
914-23
Sprache:
eng
Volltext / DOI:
doi:10.1164/rccm.201407-1381OC
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25632992
Print-ISSN:
1073-449X
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
 BibTeX