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Titel:

Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Rieber, Nikolaus; Singh, Anurag; Öz, Hasan; Carevic, Melanie; Bouzani, Maria; Amich, Jorge; Ost, Michael; Ye, Zhiyong; Ballbach, Marlene; Schäfer, Iris; Mezger, Markus; Klimosch, Sascha N; Weber, Alexander N R; Handgretinger, Rupert; Krappmann, Sven; Liese, Johannes; Engeholm, Maik; Schüle, Rebecca; Salih, Helmut Rainer; Marodi, Laszlo; Speckmann, Carsten; Grimbacher, Bodo; Ruland, Jürgen; Brown, Gordon D; Beilhack, Andreas; Loeffler, Juergen; Hartl, Dominik
Abstract:
Despite continuous contact with fungi, immunocompetent individuals rarely develop pro-inflammatory antifungal immune responses. The underlying tolerogenic mechanisms are incompletely understood. Using both mouse models and human patients, we show that infection with the human pathogenic fungi Aspergillus fumigatus and Candida albicans induces a distinct subset of neutrophilic myeloid-derived suppressor cells (MDSCs), which functionally suppress T and NK cell responses. Mechanistically, pathogeni...     »
Zeitschriftentitel:
Cell Host Microbe
Jahr:
2015
Band / Volume:
17
Heft / Issue:
4
Seitenangaben Beitrag:
507-14
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.chom.2015.02.007
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25771792
Print-ISSN:
1931-3128
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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