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Titel:

Signaling pathway STAT1 is strongly activated by IFN-? in the pathogenesis of osteoporosis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Seeliger, Claudine; Schyschka, Lilianna; Kronbach, Zienab; Wottge, Angela; Van Griensven, Martijn; Wildemann, Britt; Vester, Helen
Abstract:
Despite extensive research, the underlying pathological mechanisms of osteoporosis are not completely understood. Recent studies have indicated a distinct role for the IFN-?/STAT1 pathway in bone metabolism. An inhibitory effect of IFN-? on osteoclastogenesis has been detected and STAT1/2 has been shown to influence osteoblastic bone metabolism. So far, no data concerning the IFN-?/STAT1 pathways in osteoblasts and osteoclasts from osteoporotic and non-osteoporotic patients are available. The ai...     »
Zeitschriftentitel:
Eur J Med Res
Jahr:
2015
Band / Volume:
20
Seitenangaben Beitrag:
1
Volltext / DOI:
doi:10.1186/s40001-014-0074-4
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25563300
Print-ISSN:
0949-2321
TUM Einrichtung:
Klinik und Poliklinik für Unfallchirurgie
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