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Titel:

Presence of starch enhances in vitro biodegradation and biocompatibility of a gentamicin delivery formulation.

Dokumenttyp:
Journal Article
Autor(en):
Balmayor, Elizabeth R; Baran, Turker E; Unger, Marina; Marques, Alexandra P; Azevedo, Helena S; Reis, Rui L
Abstract:
The effect of ?-amylase degradation on the release of gentamicin from starch-conjugated chitosan microparticles was investigated up to 60 days. Scanning electron microscopic observations showed an increase in the porosity and surface roughness of the microparticles as well as reduced diameters. This was confirmed by 67% weight loss of the microparticles in the presence of ?-amylase. Over time, a highly porous matrix was obtained leading to increased permeability and increased water uptake with p...     »
Zeitschriftentitel:
J Biomed Mater Res B Appl Biomater
Jahr:
2015
Band / Volume:
103
Heft / Issue:
8
Seitenangaben Beitrag:
1610-20
Volltext / DOI:
doi:10.1002/jbm.b.33343
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25970852
Print-ISSN:
1552-4973
TUM Einrichtung:
Klinik und Poliklinik für Unfallchirurgie
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