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Titel:

Preclinical testing of drug delivery systems to bone.

Dokumenttyp:
Journal Article; Review
Autor(en):
Van Griensven, Martijn
Abstract:
Bone defects do not heal in 5-10% of the fractures. In order to enhance bone regeneration, drug delivery systems are needed. They comprise a scaffold with or without inducing factors and/or cells. To test these drug delivery systems before application in patients, they finally need to be tested in animal models. The choice of animal model depends on the main research question; is a functional or mechanistic evaluation needed? Furthermore, which type of bone defects are investigated: load-bearin...     »
Zeitschriftentitel:
Adv Drug Deliv Rev
Jahr:
2015
Band / Volume:
94
Seitenangaben Beitrag:
151-64
Volltext / DOI:
doi:10.1016/j.addr.2015.07.006
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26212157
Print-ISSN:
0169-409X
TUM Einrichtung:
Klinik und Poliklinik für Unfallchirurgie
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