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Title:

Oncogenic CARMA1 couples NF-?B and ?-catenin signaling in diffuse large B-cell lymphomas.

Document type:
Journal Article
Author(s):
Bognar, M K; Vincendeau, M; Erdmann, T; Seeholzer, T; Grau, M; Linnemann, J R; Ruland, J; Scheel, C H; Lenz, P; Ott, G; Lenz, G; Hauck, S M; Krappmann, D
Abstract:
Constitutive activation of the antiapoptotic nuclear factor-?B (NF-?B) signaling pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphomas (DLBCL). Recurrent oncogenic mutations are found in the scaffold protein CARMA1 (CARD11) that connects B-cell receptor (BCR) signaling to the canonical NF-?B pathway. We asked how far additional downstream processes are activated and contribute to the oncogenic potential of DLBCL-derived CARMA1 mutants. To this end, we...     »
Journal title abbreviation:
Oncogene
Year:
2016
Journal volume:
35
Journal issue:
32
Pages contribution:
4269-81
Language:
eng
Fulltext / DOI:
doi:10.1038/onc.2015.493
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26776161
Print-ISSN:
0950-9232
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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