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Titel:

Low density lipoprotein receptor-related protein 1 mediated endocytosis of ?1-integrin influences cell adhesion and cell migration.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Rabiej, Verena K; Pflanzner, Thorsten; Wagner, Timo; Goetze, Kristina; Storck, Steffen E; Eble, Johannes A; Weggen, Sascha; Mueller-Klieser, Wolfgang; Pietrzik, Claus U
Abstract:
The low density lipoprotein receptor-related protein 1 (LRP1) has been shown to interact with ?1-integrin and regulate its surface expression. LRP1 knock-out cells exhibit altered cytoskeleton organization and decreased cell migration. Here we demonstrate coupled endocytosis of LRP1 and ?1-integrin and the involvement of the intracellular NPxY2 motif of LRP1 in this process. Mouse embryonic fibroblasts harboring a knock in replacement of the NPxY2 motif of LRP1 by a multiple alanine cassette (AA...     »
Zeitschriftentitel:
Exp Cell Res
Jahr:
2016
Band / Volume:
340
Heft / Issue:
1
Seitenangaben Beitrag:
102-15
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.yexcr.2015.11.020
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26610862
Print-ISSN:
0014-4827
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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