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Title:

Lineage-specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3(+)-mediated leukemic phenotype.

Document type:
Journal Article; Article
Author(s):
Müller, T A; Grundler, R; Istvánffy, R; Rudelius, M; Hennighausen, L; Illert, A L; Duyster, J
Abstract:
Mutations that activate FMS-like tyrosine kinase 3 (FLT3) are frequent occurrences in acute myeloid leukemia. Two distinct types of mutations have been described: internal duplication of the juxtamembranous domain (ITD) and point mutations of the tyrosine kinase domain (TKD). Although both mutations lead to constitutive FLT3 signaling, only FLT3-ITD strongly activates signal transducer and activator of transcription 5 (STAT5). In a murine transplantation model, FLT3-ITD induces a myeloproliferat...     »
Journal title abbreviation:
Leukemia
Year:
2016
Journal volume:
30
Journal issue:
8
Pages contribution:
1725-33
Language:
eng
Fulltext / DOI:
doi:10.1038/leu.2016.72
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27046463
Print-ISSN:
0887-6924
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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