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- Title:
Secretion of Wnts is dispensable for hematopoiesis.
- Document type:
- Comment; Journal Article; Editorial Material
- Author(s):
- Oostendorp, Robert A J
- Abstract:
- In this issue of Blood, Kabiri and coworkers report the hematopoietic deletion of the endoplasmic reticulum-localized O-acyltransferase porcupine (PORCN), which is necessary for acylation of Wnts in the endoplasmic reticulum, enabling their secretion and binding to the frizzled receptors. Unexpectedly, the absence of secreted Wnt factors does not have major effects on steady-state in vivo hematopoiesis or on long-term repopulating activity of Wnt-deficient hematopoietic stem cells.
- Journal title abbreviation:
- Blood
- Year:
- 2015
- Journal volume:
- 126
- Journal issue:
- 9
- Pages contribution:
- 1051-2
- Language:
- eng
- Fulltext / DOI:
- doi:10.1182/blood-2015-07-653402
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/26316612
- Print-ISSN:
- 0006-4971
- TUM Institution:
- III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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