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Title:

Impact of comorbidities on overall survival in patients with chronic myeloid leukemia: results of the randomized CML study IV.

Document type:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Author(s):
Saussele, Susanne; Krauss, Marie-Paloma; Hehlmann, Rüdiger; Lauseker, Michael; Proetel, Ulrike; Kalmanti, Lida; Hanfstein, Benjamin; Fabarius, Alice; Kraemer, Doris; Berdel, Wolfgang E; Bentz, Martin; Staib, Peter; de Wit, Maike; Wernli, Martin; Zettl, Florian; Hebart, Holger F; Hahn, Markus; Heymanns, Jochen; Schmidt-Wolf, Ingo; Schmitz, Norbert; Eckart, Michael J; Gassmann, Winfried; Bartholomäus, Andrea; Pezzutto, Antonio; Leibundgut, Elisabeth Oppliger; Heim, Dominik; Krause, Stefan W; Burch...     »
Abstract:
We studied the influence of comorbidities on remission rate and overall survival (OS) in patients with chronic myeloid leukemia (CML). Participants of the CML Study IV, a randomized 5-arm trial designed to optimize imatinib therapy, were analyzed for comorbidities at diagnosis using the Charlson Comorbidity Index (CCI); 511 indexed comorbidities were reported in 1519 CML patients. Age was an additional risk factor in 863 patients. Resulting CCI scores were as follows: CCI 2, n = 589; CCI 3 or...     »
Journal title abbreviation:
Blood
Year:
2015
Journal volume:
126
Journal issue:
1
Pages contribution:
42-9
Language:
eng
Fulltext / DOI:
doi:10.1182/blood-2015-01-617993
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25918346
Print-ISSN:
0006-4971
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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