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Title:

The impact of a ten-week physical exercise program on health-related quality of life in patients with inflammatory bowel disease: a prospective randomized controlled trial.

Document type:
Journal Article; Article
Author(s):
Klare, Peter; Nigg, Johanna; Nold, Johannes; Haller, Bernhard; Krug, Anne B; Mair, Sebastian; Thoeringer, Christoph K; Christle, Jeffrey W; Schmid, Roland M; Halle, Martin; Huber, Wolfgang
Abstract:
Improving health-related quality of life is a primary target of therapy for patients with inflammatory bowel disease. Physical activity has been demonstrated to improve health-related quality of life in several patient populations with chronic disease. There are very few studies investigating the effects of physical activity on health-related quality of life in inflammatory bowel disease. The primary purpose of this study is to investigate the effects of 10 weeks of moderate physical activity on health-related quality of life in patients with inflammatory bowel disease.Thirty patients with mild to moderate IBD (Crohn's Disease Activity Index (CDAI) <220 or Rachmilewitz Index (RI) <11) were randomized 1:1 to either supervised moderate-intensity running thrice a week for 10 weeks or a control group who were not prescribed any exercise. Health-related quality of life, symptoms, and inflammation were assessed at baseline and after 10 weeks.Participants were 41 ± 14 years (73% female), had a body mass index of 22.8 ± 4.1 kg/m(2), and an average CDAI or RI of 66.8 ± 42.4 and 3.6 ± 3.1. No adverse events occurred during the 10-week training period. Health-related quality of life, reported as IBDQ total score, improved 19% in the intervention group and 8% in the control group. Scores for the IBDQ social sub-scale were significantly improved in the intervention group compared with controls (?IBDQsocial = 6.27 ± 5.46 vs. 1.87 ± 4.76, p = 0.023).Patients suffering from moderately active IBD are capable of performing symptom-free regular endurance exercise. Our data support the assumption that PA is feasible in IBD patients. PA may furthermore improve quality of life through improvements in social well-being, and may, therefore, be a useful adjunct to IBD therapy.
Journal title abbreviation:
Digestion
Year:
2015
Journal volume:
91
Journal issue:
3
Pages contribution:
239-47
Language:
eng
Fulltext / DOI:
doi:10.1159/000371795
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25823689
Print-ISSN:
0012-2823
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Medizinische Statistik und Epidemiologie; Poliklinik für Präventive und Rehabilitative Sportmedizin
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