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Title:

N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Banci, Lucia; Ciofi-Baffoni, Simone; Gajda, Karolina; Muzzioli, Riccardo; Peruzzini, Riccardo; Winkelmann, Julia
Abstract:
In eukaryotes, cytosolic monothiol glutaredoxins are proteins implicated in intracellular iron trafficking and sensing via their bound [2Fe-2S] clusters. We define a new role of human cytosolic monothiol glutaredoxin-3 (GRX3) in transferring its [2Fe-2S] clusters to human anamorsin, a physical and functional protein partner of GRX3 in the cytosol, whose [2Fe-2S] cluster-bound form is involved in the biogenesis of cytosolic and nuclear Fe-S proteins. Specific protein recognition between the N-ter...     »
Journal title abbreviation:
Nat Chem Biol
Year:
2015
Journal volume:
11
Journal issue:
10
Pages contribution:
772-8
Language:
eng
Fulltext / DOI:
doi:10.1038/nchembio.1892
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26302480
Print-ISSN:
1552-4450
TUM Institution:
Institut für Humangenetik
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