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Title:

A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumors.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Evangelisti, Cecilia; de Biase, Dario; Kurelac, Ivana; Ceccarelli, Claudio; Prokisch, Holger; Meitinger, Thomas; Caria, Paola; Vanni, Roberta; Romeo, Giovanni; Tallini, Giovanni; Gasparre, Giuseppe; Bonora, Elena
Abstract:
Thyroid neoplasias with oncocytic features represent a specific phenotype in non-medullary thyroid cancer, reflecting the unique biological phenomenon of mitochondrial hyperplasia in the cytoplasm. Oncocytic thyroid cells are characterized by a prominent eosinophilia (or oxyphilia) caused by mitochondrial abundance. Although disruptive mutations in the mitochondrial DNA (mtDNA) are the most significant hallmark of such tumors, oncocytomas may be envisioned as heterogeneous neoplasms, characteriz...     »
Journal title abbreviation:
BMC Cancer
Year:
2015
Journal volume:
15
Pages contribution:
157
Language:
eng
Fulltext / DOI:
doi:10.1186/s12885-015-1122-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25880213
TUM Institution:
Institut für Humangenetik
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