Prospective association of vitamin D with frailty status and all-cause mortality in older adults: Results from the KORA-Age Study.

Vogt, Susanne; Decke, Siona; de Las Heras Gala, Tonia; Linkohr, Birgit; Koenig, Wolfgang; Ladwig, Karl-Heinz; Peters, Annette; Thorand, Barbara

doi:10.1016/j.ypmed.2015.01.010

2015

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Document type:: Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):: Vogt, Susanne; Decke, Siona; de Las Heras Gala, Tonia; Linkohr, Birgit; Koenig, Wolfgang; Ladwig, Karl-Heinz; Peters, Annette; Thorand, Barbara
Title:: Prospective association of vitamin D with frailty status and all-cause mortality in older adults: Results from the KORA-Age Study.
Abstract:: To assess the prospective association of serum 25-hydroxyvitamin D [25(OH)D] levels with frailty status and all-cause mortality in a cohort of community-dwelling participants of the population-based KORA [Cooperative Health Research in the Region of Augsburg]-Age Study.727 non-frail participants, aged >=65years, with 25(OH)D measurement at baseline in 2009, were followed for 2.9±0.1years. Participants were classified as pre-frail or frail if they met 1-2 or >=3, respectively, of the following five criteria: weight loss, exhaustion, physical inactivity, low walking speed, weakness. The association between 25(OH)D and mortality was assessed in 954 participants. Multivariable adjusted logistic regression models were calculated for each outcome.The incidence of pre-frailty and frailty was 21.2% and 3.9% respectively. After multivariable adjustment, participants with very low 25(OH)D levels (<15ng/ml vs. >=30ng/ml) had a significantly higher odds for pre-frailty (OR=2.43 [95% CI: 1.17-5.03]) and pre-frailty/frailty combined (OR=2.53 [95% CI: 1.23-5.22]), but not for frailty alone (OR=2.63 [95% CI: 0.39-17.67]). The association between 25(OH)D and mortality (OR=3.39 [95% CI: 1.08-10.65]) was partly mediated by frailty status.Very low 25(OH)D levels were independently associated with incident pre-frailty, pre-frailty/frailty combined and all-cause mortality.
Journal title abbreviation:: Prev Med
Year:: 2015
Journal volume:: 73
Pages contribution:: 40-6
Language:: eng
Fulltext / DOI:: doi:10.1016/j.ypmed.2015.01.010
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/25614042
Print-ISSN:: 0091-7435
TUM Institution:: Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie (Prof. Henningsen)2015