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Title:

Class II HLA interactions modulate genetic risk for multiple sclerosis.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Moutsianas, Loukas; Jostins, Luke; Beecham, Ashley H; Dilthey, Alexander T; Xifara, Dionysia K; Ban, Maria; Shah, Tejas S; Patsopoulos, Nikolaos A; Alfredsson, Lars; Anderson, Carl A; Attfield, Katherine E; Baranzini, Sergio E; Barrett, Jeffrey; Binder, Thomas M C; Booth, David; Buck, Dorothea; Celius, Elisabeth G; Cotsapas, Chris; D'Alfonso, Sandra; Dendrou, Calliope A; Donnelly, Peter; Dubois, Bénédicte; Fontaine, Bertrand; Lar Fugger, Lars; Goris, An; Gourraud, Pierre-Antoine; Graetz, Christi...     »
Abstract:
Association studies have greatly refined the understanding of how variation within the human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the extent to which major effects are modulated by interactions is poorly characterized. We analyzed high-density SNP data on 17,465 cases and 30,385 controls from 11 cohorts of European ancestry, in combination with imputation of classical HLA alleles, to build a high-resolution map of HLA genetic risk and assess the evidence...     »
Journal title abbreviation:
Nat Genet
Year:
2015
Journal volume:
47
Journal issue:
10
Pages contribution:
1107-13
Language:
eng
Fulltext / DOI:
doi:10.1038/ng.3395
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26343388
Print-ISSN:
1061-4036
TUM Institution:
Lehrstuhl für Neurogenetik (Prof. Winkelmann); Neurologische Klinik und Poliklinik
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