Excess of rare coding variants in PLD3 in late- but not early-onset Alzheimer's disease.

Title:: Excess of rare coding variants in PLD3 in late- but not early-onset Alzheimer's disease.
Document type:: Journal Article; Journal Article
Author(s):: Schulte, Eva C; Kurz, Alexander; Alexopoulos, Panagiotis; Hampel, Harald; Peters, Annette; Gieger, Christian; Rujescu, Dan; Diehl-Schmid, Janine; Winkelmann, Juliane
Abstract:: Recently, mutations in phospholipase D3 (PLD3) were reported in late-onset Alzheimer's disease (AD). By screening the coding regions of PLD3 for variants in a European cohort of 1,089 AD cases, 182 individuals with frontotemporal lobar degeneration and 1,456 controls, we identified 32 variants with a minor allele frequency <5% and observed an excess of rare variants in individuals with late- but not early-onset AD (P=0.034, ? (2)-test; odds ratio=1.46).
Journal title abbreviation:: Hum Genome Var
Year:: 2015
Journal volume:: 2
Pages contribution:: 14028
Language:: eng
Fulltext / DOI:: doi:10.1038/hgv.2014.28
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/27081517
Print-ISSN:: 2054-345X
TUM Institution:: Institut für Humangenetik; Klinik und Poliklinik für Psychiatrie und Psychotherapie
BibTeX