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Titel:

Mitochondrial GWA Analysis of Lipid Profile Identifies Genetic Variants to Be Associated with HDL Cholesterol and Triglyceride Levels.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Flaquer, Antònia; Rospleszcz, Susanne; Reischl, Eva; Zeilinger, Sonja; Prokisch, Holger; Meitinger, Thomas; Meisinger, Christa; Peters, Annette; Waldenberger, Melanie; Grallert, Harald; Strauch, Konstantin
Abstract:
It has been suggested that mitochondrial dysfunction has an influence on lipid metabolism. The fact that mitochondrial defects can be accumulated over time as a normal part of aging may explain why cholesterol levels often are altered with age. To test the hypothesis whether mitochondrial variants are associated with lipid profile (total cholesterol, LDL, HDL, and triglycerides) we analyzed a total number of 978 mitochondrial single nucleotide polymorphisms (mtSNPs) in a sample of 2,815 individu...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2015
Band / Volume:
10
Heft / Issue:
5
Seitenangaben Beitrag:
e0126294
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0126294
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25945934
Print-ISSN:
1932-6203
TUM Einrichtung:
Institut für Humangenetik
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