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Titel:

A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumors.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Evangelisti, Cecilia; de Biase, Dario; Kurelac, Ivana; Ceccarelli, Claudio; Prokisch, Holger; Meitinger, Thomas; Caria, Paola; Vanni, Roberta; Romeo, Giovanni; Tallini, Giovanni; Gasparre, Giuseppe; Bonora, Elena
Abstract:
Thyroid neoplasias with oncocytic features represent a specific phenotype in non-medullary thyroid cancer, reflecting the unique biological phenomenon of mitochondrial hyperplasia in the cytoplasm. Oncocytic thyroid cells are characterized by a prominent eosinophilia (or oxyphilia) caused by mitochondrial abundance. Although disruptive mutations in the mitochondrial DNA (mtDNA) are the most significant hallmark of such tumors, oncocytomas may be envisioned as heterogeneous neoplasms, characteriz...     »
Zeitschriftentitel:
BMC Cancer
Jahr:
2015
Band / Volume:
15
Seitenangaben Beitrag:
157
Sprache:
eng
Volltext / DOI:
doi:10.1186/s12885-015-1122-3
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25880213
TUM Einrichtung:
Institut für Humangenetik
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