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Title:

Nanofiltrated C1-esterase-inhibitor in the prophylactic treatment of bradykinin-mediated angioedema.

Document type:
Journal Article; Article
Author(s):
Greve, Jens; Hahn, Janina; Nordmann, Melanie; Schuler, Patrick J; Bas, Murat; Hoffmann, Thomas K; Hajdu, Zuzana; Buchberger, Maria; Strassen, Ulrich
Abstract:
Patients suffering from bradykinin-induced angioedema show recurrent swelling of subcutaneous and submucosal structures. Increased bradykinin levels lead to an increase in vascular permeability and edema formation. Current therapy consists of B2 bradykinin receptor antagonists, C1-esterase-inhibitor (C1-INH) concentrate, or the kallikrein inhibitor ecallantide. In most cases the treatment of acute attacks is sufficient. Prophylactic therapy is recommended only in severe cases. C1-INHc has been s...     »
Journal title abbreviation:
Transfusion
Year:
2016
Journal volume:
56
Journal issue:
5
Pages contribution:
1022-9
Language:
eng
Fulltext / DOI:
doi:10.1111/trf.13462
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26756974
Print-ISSN:
0041-1132
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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