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Title:

Aspergillus fumigatus devoid of cell wall ?-1,3-glucan is viable, massively sheds galactomannan and is killed by septum formation inhibitors.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Dichtl, Karl; Samantaray, Sweta; Aimanianda, Vishukumar; Zhu, Zhaojun; Prévost, Marie-Christine; Latgé, Jean-Paul; Ebel, Frank; Wagener, Johannes
Abstract:
Echinocandins inhibit ?-1,3-glucan synthesis and are one of the few antimycotic drug classes effective against Aspergillus spp. In this study, we characterized the ?-1,3-glucan synthase Fks1 of Aspergillus fumigatus, the putative target of echinocandins. Data obtained with a conditional mutant suggest that fks1 is not essential. In agreement, we successfully constructed a viable ?fks1 deletion mutant. Lack of Fks1 results in characteristic growth phenotypes similar to wild type treated with echi...     »
Journal title abbreviation:
Mol Microbiol
Year:
2015
Journal volume:
95
Journal issue:
3
Pages contribution:
458-71
Language:
eng
Fulltext / DOI:
doi:10.1111/mmi.12877
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25425041
Print-ISSN:
0950-382X
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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