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Title:

Mitochondrial dynamics in the pathogenic mold Aspergillus fumigatus: therapeutic and evolutionary implications.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Neubauer, Michael; Zhu, Zhaojun; Penka, Mirjam; Helmschrott, Christoph; Wagener, Nikola; Wagener, Johannes
Abstract:
Mitochondria within eukaryotic cells continuously fuse and divide. This phenomenon is called mitochondrial dynamics and crucial for mitochondrial function and integrity. We performed a comprehensive analysis of mitochondrial dynamics in the pathogenic mold Aspergillus fumigatus. Phenotypic characterization of respective mutants revealed the general essentiality of mitochondrial fusion for mitochondrial genome maintenance and the mold's viability. Surprisingly, it turned out that the mitochondria...     »
Journal title abbreviation:
Mol Microbiol
Year:
2015
Journal volume:
98
Journal issue:
5
Pages contribution:
930-45
Language:
eng
Fulltext / DOI:
doi:10.1111/mmi.13167
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26272083
Print-ISSN:
0950-382X
TUM Institution:
Hals-Nasen-Ohrenklinik und Poliklinik
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