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Titel:

Effects of topoisomerase inhibitors that induce DNA damage response on glucose metabolism and PI3K/Akt/mTOR signaling in multiple myeloma cells.

Dokumenttyp:
Journal Article; Article
Autor(en):
Demel, Hans-Richard; Feuerecker, Benedikt; Piontek, Guido; Seidl, Christof; Blechert, Birgit; Pickhard, Anja; Essler, Markus
Abstract:
Hallmarks of cancer cells comprise altered glucose metabolism (aerobic glycolysis) and differences in DNA damage response (DDR). Glucose transporters (GLUT), glycolytic enzymes such as hexokinase (HK) and metabolic pathways (e.g. PI3K/Akt/mTor) have been shown to be upregulated in multiple myeloma and other cancer cell lines. Here we have investigated the effects of clinically used inhibitors of topoisomerases, of DDR and of the PI3K/Akt/mTor pathway on glucose metabolism and on cell survival in...     »
Zeitschriftentitel:
Am J Cancer Res
Jahr:
2015
Band / Volume:
5
Heft / Issue:
5
Seitenangaben Beitrag:
1649-64
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26175935
TUM Einrichtung:
Frauenklinik und Poliklinik; Hals-Nasen-Ohrenklinik und Poliklinik; Klinik und Poliklinik für Nuklearmedizin
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