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Title:

NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk.

Document type:
Journal Article
Abstract:
A recent study by Wang et al. (2016a) claims that the low-frequency variant NR1H3 p.Arg415Gln is sufficient to cause multiple sclerosis in certain individuals and determines a patient's likelihood of primary progressive disease. We sought to replicate this finding in the International MS Genetics Consortium (IMSGC) patient collection, which is 13-fold larger than the collection of Wang et al. (2016a), but we find no evidence that this variant is associated with either MS or disease subtype. Wang...     »
Journal title abbreviation:
Neuron
Year:
2016
Journal volume:
92
Journal issue:
2
Pages contribution:
333-335
Language:
eng
Fulltext / DOI:
doi:10.1016/j.neuron.2016.09.052
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27764667
Print-ISSN:
0896-6273
TUM Institution:
Neurologische Klinik und Poliklinik
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