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Titel:

CNS accumulation of regulatory B cells is VLA-4-dependent.

Dokumenttyp:
Journal Article
Autor(en):
Lehmann-Horn, Klaus; Sagan, Sharon A; Winger, Ryan C; Spencer, Collin M; Bernard, Claude C A; Sobel, Raymond A; Zamvil, Scott S
Abstract:
To investigate the role of very late antigen-4 (VLA-4) on regulatory B cells (Breg) in CNS autoimmune disease.Experimental autoimmune encephalomyelitis (EAE) was induced in mice selectively deficient for VLA-4 on B cells (CD19cre/?4(f/f)) by immunization with myelin oligodendrocyte glycoprotein (MOG) peptide (p)35-55 or recombinant human (rh) MOG protein. B-cell and T-cell populations were examined by flow cytometry and immunohistochemistry. Breg were evaluated by intracellular IL-10 staining of...     »
Zeitschriftentitel:
Neurol Neuroimmunol Neuroinflamm
Jahr:
2016
Band / Volume:
3
Heft / Issue:
2
Seitenangaben Beitrag:
e212
Sprache:
eng
Volltext / DOI:
doi:10.1212/NXI.0000000000000212
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27027096
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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