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Titel:

B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue.

Dokumenttyp:
Journal Article
Autor(en):
Lehmann-Horn, Klaus; Wang, Sheng-Zhi; Sagan, Sharon A; Zamvil, Scott S; von Büdingen, H-Christian
Abstract:
Ectopic lymphoid tissues (ELT) can be found in multiple sclerosis (MS) and other organ-specific inflammatory conditions. Whether ELT in the meninges of central nervous system (CNS) autoimmune disease exhibit local germinal center (GC) activity remains unknown. In an experimental autoimmune encephalomyelitis model of CNS autoimmunity, we found activation-induced cytidine deaminase, a GC-defining enzyme, in meningeal ELT (mELT) densely populated by B and T cells. To determine GC activity in mELT,...     »
Zeitschriftentitel:
JCI Insight
Jahr:
2016
Band / Volume:
1
Heft / Issue:
20
Seitenangaben Beitrag:
e87234
Sprache:
eng
Volltext / DOI:
doi:10.1172/jci.insight.87234
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27942581
Print-ISSN:
2379-3708
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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