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Title:

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery.

Document type:
Journal Article
Author(s):
Mei, Feng; Lehmann-Horn, Klaus; Shen, Yun-An A; Rankin, Kelsey A; Stebbins, Karin J; Lorrain, Daniel S; Pekarek, Kara; A Sagan, Sharon; Xiao, Lan; Teuscher, Cory; von Büdingen, H-Christian; Wess, Jürgen; Lawrence, J Josh; Green, Ari J; Fancy, Stephen Pj; Zamvil, Scott S; Chan, Jonah R
Abstract:
Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss. Inflammatory demyelination is accompanied by significant neuronal loss in the experimental autoimmune encephalomyelitis (EAE) mouse model and evidence for remyelination in this model is complicated by ongoing inflammation, degeneration and possible remyelination. Demonstrating the functional sign...     »
Journal title abbreviation:
Elife
Year:
2016
Journal volume:
5
Language:
eng
Fulltext / DOI:
doi:10.7554/eLife.18246
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27671734
TUM Institution:
Neurologische Klinik und Poliklinik
 BibTeX