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Title:

Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis.

Document type:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Article
Author(s):
Vercruysse, Pauline; Sinniger, Jérôme; El Oussini, Hajer; Scekic-Zahirovic, Jelena; Dieterlé, Stéphane; Dengler, Reinhard; Meyer, Thomas; Zierz, Stephan; Kassubek, Jan; Fischer, Wilhelm; Dreyhaupt, Jens; Grehl, Torsten; Hermann, Andreas; Grosskreutz, Julian; Witting, Anke; Van Den Bosch, Ludo; Spreux-Varoquaux, Odile; Ludolph, Albert C; Dupuis, Luc
Abstract:
Amyotrophic lateral sclerosis, the most common adult-onset motor neuron disease, leads to death within 3 to 5 years after onset. Beyond progressive motor impairment, patients with amyotrophic lateral sclerosis suffer from major defects in energy metabolism, such as weight loss, which are well correlated with survival. Indeed, nutritional intervention targeting weight loss might improve survival of patients. However, the neural mechanisms underlying metabolic impairment in patients with amyotroph...     »
Journal title abbreviation:
Brain
Year:
2016
Journal volume:
139
Journal issue:
Pt 4
Pages contribution:
1106-22
Language:
eng
Fulltext / DOI:
doi:10.1093/brain/aww004
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26984187
Print-ISSN:
0006-8950
TUM Institution:
Neurologische Klinik und Poliklinik
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