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Titel:

Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis.

Dokumenttyp:
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Article
Autor(en):
Vercruysse, Pauline; Sinniger, Jérôme; El Oussini, Hajer; Scekic-Zahirovic, Jelena; Dieterlé, Stéphane; Dengler, Reinhard; Meyer, Thomas; Zierz, Stephan; Kassubek, Jan; Fischer, Wilhelm; Dreyhaupt, Jens; Grehl, Torsten; Hermann, Andreas; Grosskreutz, Julian; Witting, Anke; Van Den Bosch, Ludo; Spreux-Varoquaux, Odile; Ludolph, Albert C; Dupuis, Luc
Abstract:
Amyotrophic lateral sclerosis, the most common adult-onset motor neuron disease, leads to death within 3 to 5 years after onset. Beyond progressive motor impairment, patients with amyotrophic lateral sclerosis suffer from major defects in energy metabolism, such as weight loss, which are well correlated with survival. Indeed, nutritional intervention targeting weight loss might improve survival of patients. However, the neural mechanisms underlying metabolic impairment in patients with amyotroph...     »
Zeitschriftentitel:
Brain
Jahr:
2016
Band / Volume:
139
Heft / Issue:
Pt 4
Seitenangaben Beitrag:
1106-22
Sprache:
eng
Volltext / DOI:
doi:10.1093/brain/aww004
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26984187
Print-ISSN:
0006-8950
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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