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Titel:

Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide.

Dokumenttyp:
Journal Article; Article
Autor(en):
Wick, Wolfgang; Roth, Patrick; Hartmann, Christian; Hau, Peter; Nakamura, Makoto; Stockhammer, Florian; Sabel, Michael C; Wick, Antje; Koeppen, Susanne; Ketter, Ralf; Vajkoczy, Peter; Eyupoglu, Ilker; Kalff, Rolf; Pietsch, Torsten; Happold, Caroline; Galldiks, Norbert; Schmidt-Graf, Friederike; Bamberg, Michael; Reifenberger, Guido; Platten, Michael; von Deimling, Andreas; Meisner, Christoph; Wiestler, Benedikt; Weller, Michael
Abstract:
Optimal treatment and precise classification for anaplastic glioma are needed.The objective for long-term follow-up of NOA-04 is to optimize the treatment sequence for patients with anaplastic gliomas. Patients were randomized 2:1:1 to receive the standard radiotherapy (RT) (arm A), procarbazine, lomustine and vincristine (PCV) (arm B1), or temozolomide (TMZ) (arm B2).Primary endpoint was time-to-treatment-failure (TTF), defined as progression after 2 lines of therapy or any time before if no fu...     »
Zeitschriftentitel:
Neuro-oncol
Jahr:
2016
Band / Volume:
18
Heft / Issue:
11
Seitenangaben Beitrag:
1529-1537
Sprache:
eng
Volltext / DOI:
doi:10.1093/neuonc/now133
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27370396
Print-ISSN:
1522-8517
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer); Neurologische Klinik und Poliklinik
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