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Titel:

Biomimetic biosensor to distinguish between inhibitory and non-inhibitory factor VIII antibodies.

Dokumenttyp:
Journal Article
Autor(en):
Kocot, Carmen; Schindler, Aline R; Le Blanc, Alexander; Schmalenberg, Michael; Miesbach, Wolfgang; Spannagl, Michael; Luppa, Peter B
Abstract:
Patients with hereditary or acquired haemophilia A may develop inhibitory factor VIII (FVIII) antibodies. These disrupt FVIII activity predominantly by preventing the formation of the tenase complex, leading to a serious bleeding disorder. Antibodies without inhibiting activity, however, can also be found when screening patients with haemophilia A under FVIII supplementation. Therefore, the detection of only these allo- or autoantibodies from plasma is not sufficient. Rather, the characterizatio...     »
Zeitschriftentitel:
Anal Bioanal Chem
Jahr:
2015
Band / Volume:
407
Heft / Issue:
19
Seitenangaben Beitrag:
5685-93
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00216-015-8751-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25957847
Print-ISSN:
1618-2642
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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