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Title:

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review; Review
Author(s):
Feitelson, Mark A; Arzumanyan, Alla; Kulathinal, Rob J; Blain, Stacy W; Holcombe, Randall F; Mahajna, Jamal; Marino, Maria; Martinez-Chantar, Maria L; Nawroth, Roman; Sanchez-Garcia, Isidro; Sharma, Dipali; Saxena, Neeraj K; Singh, Neetu; Vlachostergios, Panagiotis J; Guo, Shanchun; Honoki, Kanya; Fujii, Hiromasa; Georgakilas, Alexandros G; Bilsland, Alan; Amedei, Amedeo; Niccolai, Elena; Amin, Amr; Ashraf, S Salman; Boosani, Chandra S; Guha, Gunjan; Ciriolo, Maria Rosa; Aquilano, Katia; Chen, S...     »
Abstract:
Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related proteins. Constitutive activation of many signal transduction pathways also stimulates cell growth. Early steps in tumor development are associated with a fibrogenic response and the development of a hypoxic environment which favors the survival and proliferation of cancer stem cells. Part of the survival strategy of cancer stem cells may manifest...     »
Journal title abbreviation:
Semin Cancer Biol
Year:
2015
Journal volume:
35 Suppl
Pages contribution:
S25-54
Language:
eng
Fulltext / DOI:
doi:10.1016/j.semcancer.2015.02.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25892662
Print-ISSN:
1044-579X
TUM Institution:
Urologische Klinik und Poliklinik
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