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Titel:

DCA promotes progression of neuroblastoma tumors in nude mice.

Dokumenttyp:
Journal Article; Article
Autor(en):
Feuerecker, Benedikt; Seidl, Christof; Pirsig, Sabine; Bruchelt, Gernot; Senekowitsch-Schmidtke, Reingard
Abstract:
Even in the presence of oxygen most cancer cells convert glucose to lactate via pyruvate instead of performing oxidative phosphorylation (aerobic glycolysis-Warburg effect). Thus, it has been considered to shift pyruvate - the metabolite of aerobic glycolysis - to acetylCoA by activation of pyruvate dehydrogenase (PDH). AcetylCoA will then be metabolized by oxidative phosphorylation. Therefore, the purpose of this study was to shift tumor cells from aerobic glycolysis to oxidative phosphorylatio...     »
Zeitschriftentitel:
Am J Cancer Res
Jahr:
2015
Band / Volume:
5
Heft / Issue:
2
Seitenangaben Beitrag:
812-20
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25973318
TUM Einrichtung:
Frauenklinik und Poliklinik; Klinik und Poliklinik für Nuklearmedizin
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