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Title:

Metabolic imaging of hyperpolarized [1-(13) C]acetate and [1-(13) C]acetylcarnitine - investigation of the influence of dobutamine induced stress.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Koellisch, Ulrich; Gringeri, Concetta V; Rancan, Giaime; Farell, Eliane V; Menzel, Marion I; Haase, Axel; Schwaiger, Markus; Schulte, Rolf F
Abstract:
The metabolism of acetate in the heart resembles fatty acid metabolism, which is altered in several diseases like ischemia, diabetes mellitus, and heart failure. A signal-to-noise ratio (SNR) optimized imaging framework for in vivo measurements of hyperpolarized [1-(13) C]acetate and its metabolic product [1-(13) C]acetylcarnitine (ALCAR) in rats at 3 Tesla (T) is presented in this work.A spectrospatial pulse was combined with IDEAL encoding to acquire well separated metabolic maps. The influenc...     »
Journal title abbreviation:
Magn Reson Med
Year:
2015
Journal volume:
74
Journal issue:
4
Pages contribution:
1011-8
Language:
eng
Fulltext / DOI:
doi:10.1002/mrm.25485
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25298189
Print-ISSN:
0740-3194
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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