mediaTUM
Universitätsbibliothek
Technische Universität München
User: Guest
Login
de
en
All data
Titel
Autor
Jahr
All data
Titel
Autor
Jahr
All data
Titel
Autor
Jahr
All data
Titel
Autor
Jahr
All data
Titel
Autor
Jahr
All data
Titel
Autor
Jahr
All data
Titel
Autor
Jahr
All data
Titel
Autor
Jahr
All data
Titel
Autor
Jahr
All data
Titel
Autor
Jahr
Less Searchfields
Reset
Search
Simple search
mediaTUM Content
University Bibliography
Electronic Examination Papers
Open Access Publikationen
Research Data
TUM.University Press
Collections
Projects
Institutions
Research Centers
TUM Board of Management
Functional Units
Partnerschaftliche Einrichtungen
Schools
TUM School of Computation, Information and Technology
(44602)
TUM School of Engineering and Design
Center of Life and Food Sciences Weihenstephan
TUM School of Management
TUM School of Medicine and Health
Deanery
(6)
Examination Papers
(5936)
Departments
(46272)
2023
(3)
Preclinical Medicine
(5195)
Health and Sport Sciences
Clinical Medicine
(36013)
Institute of General Medicine (Prof. Schneider)
(322)
Institute of Radiology (Prof. Makowski)
(3397)
Institute of Experimental Hematology (Prof. Schmidt-Supprian)
(43)
Institute of Experimental Neuroimmunology (Prof. Korn)
(1)
Institute of Exerimentelle Tumortherapie (Prof. Saur)
(140)
Institute of Human Genetics (Prof. Winkelmann)
(1063)
Institute of AI and Informatics in Medicine (Prof. Rückert)
(1638)
Institute of Clinical Chemistry and Pathobiochemistry (Prof. Ruland)
(420)
Institute of Molecular Allergology (Prof. Schmidt-Weber)
(692)
Institute of Molecular Immunology (Prof. Knolle)
(139)
Institute of Molecular Oncology and Functional Genomics (Prof. Rad)
(115)
Department of Anesthesiology and Intensive Care (Prof. Schneider)
(742)
Clinic of Nutritional Medicine (Prof. Hauner)
(609)
Department of Ophthalmology
(340)
Department of Surgery (Prof. Friess)
(1707)
Department of Dermatology and Allergology (Prof. Biedermann)
(2194)
Department of Gynecology (Prof. Kiechle)
(1533)
Department of Otolaryngology (Prof. Wollenberg)
(622)
Department of Internal Medicine I - Cardiology (Prof. Laugwitz)
(1531)
Department of Internal Medicine II - Gastroenterology (Prof. Schmid)
(2384)
Department of Internal Medicine III - Hematology and Medical Oncology (Prof. Bassermann)
(1338)
Department of Pediatric Medicine (Prof. Hauer)
(1035)
Department of Oral and Maxillofacial Surgery (Prof. Wolff)
(483)
Clinic and Polyclinic for Neonatology (Prof. Peters komm.)
(6)
Department of Neurosurgery (Prof. Meyer)
(762)
Department of Neurology (Prof. Hemmer)
(2486)
Department of Nuclear Medicine (Prof. Weber)
(1891)
2024
(8)
Assistant Professorship of Biomedical Magnetic Resonance (Prof. Schilling)
2023
(122)
Assistant Professorship of Imaging and Biomarkers in Oncology (Prof. Kossatz)
Chair of Nuclear Medicine (Prof. Weber)
(6)
2022
(89)
2021
(105)
2020
(95)
2019
(89)
2018
(101)
2017
(97)
2016
(100)
2015
(106)
2014
(80)
2013
(81)
2012
(65)
2011
(67)
2010
(67)
2009
(89)
2008
(93)
2007
(93)
2006
(79)
2005
(78)
2004
(83)
2003
(75)
2002
(3)
2001
(1)
Department of Orthopedics and Sports Orthopedics (Prof. von Eisenhart-Rothe)
(1002)
Department of Plastic Surgery and Hand Surgery (Prof. Machens)
(473)
Department of Psychiatry and Psychotherapy (Prof. Priller)
(1859)
Department of Psychosomatic Medicine and Psychotherapy (Prof. Henningsen)
(1030)
Department of Radiooncology and Radiation Therapy (Prof. Combs)
(1490)
Department of Trauma Surgery (Prof. Biberthaler)
(749)
Department of Urology (Prof. Gschwend)
(1014)
Clinic and Polyclinic for Vascular and Endovascular Surgery (Prof. Eckstein)
(689)
German Heart Centre Munich
(3075)
Department of Preventive Sports Medicine and Sports Cardiology (Prof. Halle)
(495)
Weitere Lehrstühle und Professuren Clinical Medicine
(173)
2022
(37)
2021
(25)
2020
(25)
2019
(17)
2018
(6)
2017
(12)
2016
(9)
2015
(18)
2014
(25)
2013
(23)
2012
(29)
Interdisziplinäres Zentrum für Zelltherapie
Roman Herzog Comprehensive Cancer Center
(183)
School Office
Zentrum für Präklinische Forschung
Ehemalige Einrichtungen
(2180)
TUM School of Natural Sciences
(14119)
TUM School of Social Sciences and Technology
(8911)
TUM Campus Straubing für Biotechnologie und Nachhaltigkeit
Service Facilities
TUM Institute for LifeLong Learning
Central Administration
mediaTUM Gesamtbestand
Einrichtungen
Schools
TUM School of Medicine and Health
Departments
Clinical Medicine
Klinik und Poliklinik für Nuklearmedizin (Prof. Weber)
2016
Back
Back to start of result list
Permanent link for displayed object
Document type:
Journal Article
Author(s):
Düwel, Stephan; Durst, Markus; Gringeri, Concetta V; Kosanke, Yvonne; Gross, Claudia; Janich, Martin A; Haase, Axel; Glaser, Steffen J; Schwaiger, Markus; Schulte, Rolf F; Braren, Rickmer; Menzel, Marion I
Title:
Multiparametric human hepatocellular carcinoma characterization and therapy response evaluation by hyperpolarized (13) C MRSI.
Abstract:
Individual tumor characterization and treatment response monitoring based on current medical imaging methods remain challenging. This work investigates hyperpolarized (13) C compounds in an orthotopic rat hepatocellular carcinoma (HCC) model system before and after transcatheter arterial embolization (TAE). HCC ranks amongst the top six most common cancer types in humans and accounts for one-third of cancer-related deaths worldwide. Early therapy response monitoring could aid in the development of personalized therapy approaches and novel therapeutic concepts. Measurements with selectively (13) C-labeled and hyperpolarized urea, pyruvate and fumarate were performed in tumor-bearing rats before and after TAE. Two-dimensional, slice-selective MRSI was used to obtain spatially resolved maps of tumor perfusion, cell energy metabolic conversion rates and necrosis, which were additionally correlated with immunohistochemistry. All three injected compounds, taken together with their respective metabolites, exhibited similar signal distributions. TAE induced a decrease in blood flow into the tumor and thus a decrease in tumor to muscle and tumor to liver ratios of urea, pyruvate and its metabolites, alanine and lactate, whereas conversion rates remained stable or increased on TAE in tumor, muscle and liver tissue. Conversion from fumarate to malate successfully indicated individual levels of necrosis, and global malate signals after TAE suggested the washout of fumarase or malate itself on necrosis. This study presents a combination of three (13) C compounds as novel candidate biomarkers for a comprehensive characterization of genetically and molecularly diverse HCC using hyperpolarized MRSI, enabling the simultaneous detection of differences in tumor perfusion, metabolism and necrosis. If, as in this study, bolus dynamics are not required and qualitative perfusion information is sufficient, the desired information could be extracted from hyperpolarized fumarate and pyruvate alone, acquired at higher fields with better spectral separation. Copyright © 2016 John Wiley & Sons, Ltd.
Journal title abbreviation:
NMR Biomed
Year:
2016
Journal volume:
29
Journal issue:
7
Pages contribution:
952-60
Language:
eng
Fulltext / DOI:
doi:10.1002/nbm.3561
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27195474
Print-ISSN:
0952-3480
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
BibTeX
Occurrences:
mediaTUM Gesamtbestand
Einrichtungen
Schools
TUM School of Medicine and Health
Departments
Clinical Medicine
Klinik und Poliklinik für Nuklearmedizin (Prof. Weber)
2016