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Document type:
Journal Article
Author(s):
Didovic, Sonja; Opitz, Friederike V; Holzmann, Bernhard; Förster, Irmgard; Weighardt, Heike
Title:
Requirement of MyD88 signaling in keratinocytes for Langerhans cell migration and initiation of atopic dermatitis-like symptoms in mice.
Abstract:
Atopic dermatitis (AD) is a chronic inflammatory disease controlled by the innate and adaptive immune system. To elucidate the impact of innate immune signaling in AD, we analyzed MyD88-deficient mice in a murine model of AD-like dermatitis by epicutaneous sensitization with ovalbumin (OVA). Global MyD88 deficiency led to reduced epidermal thickening and diminished accumulation of macrophages within the inflamed skin. In addition, we observed impaired emigration of Langerhans cells (LCs) out of...     »
Journal title abbreviation:
Eur J Immunol
Year:
2016
Journal volume:
46
Journal issue:
4
Pages contribution:
981-92
Language:
eng
Fulltext / DOI:
doi:10.1002/eji.201545710
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26694221
Print-ISSN:
0014-2980
TUM Institution:
Chirurgische Klinik und Poliklinik
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