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Document type:
Journal Article; Article 
Author(s):
Lesina, Marina; Wörmann, Sonja Maria; Morton, Jennifer; Diakopoulos, Kalliope Nina; Korneeva, Olga; Wimmer, Margit; Einwächter, Henrik; Sperveslage, Jan; Demir, Ihsan Ekin; Kehl, Timo; Saur, Dieter; Sipos, Bence; Heikenwälder, Mathias; Steiner, Jörg Manfred; Wang, Timothy Cragin; Sansom, Owen J; Schmid, Roland Michael; Algül, Hana 
Title:
RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis. 
Abstract:
Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. Here, we have determined that nuclear RelA reinforces OIS to inhibit carcinogenesis in the Kras mouse model of PDAC. Inactivation of RelA accelerated pancreatic lesion formation in Kras mice by abrogating the senescence-associated secretory phenotype...    »
 
Journal title abbreviation:
J Clin Invest 
Year:
2016 
Journal volume:
126 
Journal issue:
Pages contribution:
2919-32 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0021-9738 
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie)