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Titel:

Administration of Gemcitabine After Pancreatic Tumor Resection in Mice Induces an Antitumor Immune Response Mediated by Natural Killer Cells.

Dokumenttyp:
Journal Article; Article
Autor(en):
Gürlevik, Engin; Fleischmann-Mundt, Bettina; Brooks, Jennifer; Demir, Ihsan Ekin; Steiger, Katja; Ribback, Silvia; Yevsa, Tetyana; Woller, Norman; Kloos, Arnold; Ostroumov, Dmitrij; Armbrecht, Nina; Manns, Michael P; Dombrowski, Frank; Saborowski, Michael; Kleine, Moritz; Wirth, Thomas C; Oettle, Helmut; Ceyhan, Güralp O; Esposito, Irene; Calvisi, Diego F; Kubicka, Stefan; Kühnel, Florian
Abstract:
Even after potentially curative R0 resection, patients with pancreatic ductal adenocarcinoma (PDAC) have a poor prognosis owing to high rates of local recurrence and metastasis to distant organs. However, we have no suitable transgenic animal models for surgical interventions.To induce formation of pancreatic tumor foci, we electroporated oncogenic plasmids into pancreata of LSL-KrasG12D × p53fl/fl mice; mutant Kras was expressed in p53fl/fl mice using a sleeping beauty transposon. We co-delive...     »
Zeitschriftentitel:
Gastroenterology
Jahr:
2016
Band / Volume:
151
Heft / Issue:
2
Seitenangaben Beitrag:
338-350.e7
Sprache:
eng
Volltext / DOI:
doi:10.1053/j.gastro.2016.05.004
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27210037
Print-ISSN:
0016-5085
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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