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Titel:

Gastric Adenocarcinomas Express the Glycosphingolipid Gb3/CD77: Targeting of Gastric Cancer Cells with Shiga Toxin B-Subunit.

Dokumenttyp:
Journal Article; Article
Autor(en):
Geyer, Philipp Emanuel; Maak, Matthias; Nitsche, Ulrich; Perl, Markus; Novotny, Alexander; Slotta-Huspenina, Julia; Dransart, Estelle; Holtorf, Anne; Johannes, Ludger; Janssen, Klaus-Peter
Abstract:
The B-subunit of the bacterial Shiga toxin (STxB), which is nontoxic and has low immunogenicity, can be used for tumor targeting of breast, colon, and pancreatic cancer. Here, we tested whether human gastric cancers, which are among the most aggressive tumor entities, express the cellular receptor of Shiga toxin, the glycosphingolipid globotriaosylceramide (Gb3/CD77). The majority of cases showed an extensive staining for Gb3 (36/50 cases, 72%), as evidenced on tissue sections of surgically rese...     »
Zeitschriftentitel:
Mol Cancer Ther
Jahr:
2016
Band / Volume:
15
Heft / Issue:
5
Seitenangaben Beitrag:
1008-17
Sprache:
eng
Volltext / DOI:
doi:10.1158/1535-7163.MCT-15-0633
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26826119
Print-ISSN:
1535-7163
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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