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Titel:

Loss of Periostin Results in Impaired Regeneration and Pancreatic Atrophy after Cerulein-Induced Pancreatitis.

Dokumenttyp:
Journal Article; Article
Autor(en):
Hausmann, Simone; Regel, Ivonne; Steiger, Katja; Wagner, Nadine; Thorwirth, Manja; Schlitter, Anna M; Esposito, Irene; Michalski, Christoph W; Friess, Helmut; Kleeff, Jörg; Erkan, Mert
Abstract:
The extracellular matrix molecule periostin (POSTN, encoded by POSTN), which is secreted by activated pancreatic stellate cells, has important functions in chronic pancreatitis and pancreatic cancer. However, the role of POSTN in acute pancreatitis and subsequent regeneration processes has not been addressed so far. We analyzed the function of POSTN in pancreatic exocrine regeneration after the induction of a severe acute pancreatitis. Postn-deficient mice and wild-type control animals received...     »
Zeitschriftentitel:
Am J Pathol
Jahr:
2016
Band / Volume:
186
Heft / Issue:
1
Seitenangaben Beitrag:
24-31
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.ajpath.2015.09.022
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26632158
Print-ISSN:
0002-9440
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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