Postoperative peak serum C-reactive protein is a predictor of outcome following liver transplantation for hepatocellular carcinoma.

Title:: Postoperative peak serum C-reactive protein is a predictor of outcome following liver transplantation for hepatocellular carcinoma.
Document type:: Journal Article
Author(s):: Kornberg, Arno; Witt, Ulrike; Kornberg, Jennifer; Müller, Katharina; Friess, Helmut; Thrum, Katharina
Abstract:: C-reactive protein (CRP), a biomarker of inflammation, may correlate with prognosis in several malignancies.To investigate the prognostic impact of early postoperative peak serum levels of CRP on tumor-specific outcome in 106 liver transplant patients with hepatocellular carcinoma (HCC).In multivariate Cox regression analysis, a posttransplant elevated peak CRP level (>versus <= 3.5 mg/dl) was identified as an independent predictor of poor recurrence-free survival (p = 0.01; HR = 4.04; CI = 1.399-11.640).Early postoperative serum CRP may serve as a useful inflammation-based biomarker of outcome in liver transplant patients with HCC.
Journal title abbreviation:: Biomarkers
Year:: 2016
Journal volume:: 21
Journal issue:: 2
Pages contribution:: 152-9
Language:: eng
Fulltext / DOI:: doi:10.3109/1354750X.2015.1118548
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/26643974
Print-ISSN:: 1354-750X
TUM Institution:: Chirurgische Klinik und Poliklinik
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