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Titel:

Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia--can findings from animal models be translated to humans?

Dokumenttyp:
Journal Article; Review
Autor(en):
Mueller, Tara C; Bachmann, Jeannine; Prokopchuk, Olga; Friess, Helmut; Martignoni, Marc E
Abstract:
Cachexia is a multi-factorial, systemic syndrome that especially affects patients with cancer of the gastrointestinal tract, and leads to reduced treatment response, survival and quality of life. The most important clinical feature of cachexia is the excessive wasting of skeletal muscle mass. Currently, an effective treatment is still lacking and the search for therapeutic targets continues. Even though a substantial number of animal studies have contributed to a better understanding of the unde...     »
Zeitschriftentitel:
BMC Cancer
Jahr:
2016
Band / Volume:
16
Seitenangaben Beitrag:
75
Sprache:
eng
Volltext / DOI:
doi:10.1186/s12885-016-2121-8
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26856534
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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