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Titel:

RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis.

Dokumenttyp:
Journal Article; Article
Autor(en):
Lesina, Marina; Wörmann, Sonja Maria; Morton, Jennifer; Diakopoulos, Kalliope Nina; Korneeva, Olga; Wimmer, Margit; Einwächter, Henrik; Sperveslage, Jan; Demir, Ihsan Ekin; Kehl, Timo; Saur, Dieter; Sipos, Bence; Heikenwälder, Mathias; Steiner, Jörg Manfred; Wang, Timothy Cragin; Sansom, Owen J; Schmid, Roland Michael; Algül, Hana
Abstract:
Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. Here, we have determined that nuclear RelA reinforces OIS to inhibit carcinogenesis in the Kras mouse model of PDAC. Inactivation of RelA accelerated pancreatic lesion formation in Kras mice by abrogating the senescence-associated secretory phenotype...     »
Zeitschriftentitel:
J Clin Invest
Jahr:
2016
Band / Volume:
126
Heft / Issue:
8
Seitenangaben Beitrag:
2919-32
Sprache:
eng
Volltext / DOI:
doi:10.1172/JCI86477
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27454298
Print-ISSN:
0021-9738
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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