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Titel:

Prognostic Impact of Modulators of G proteins in Circulating Tumor Cells from Patients with Metastatic Colorectal Cancer.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Barbazán, Jorge; Dunkel, Ying; Li, Hongying; Nitsche, Ulrich; Janssen, Klaus-Peter; Messer, Karen; Ghosh, Pradipta
Abstract:
The consequence of a loss of balance between G-protein activation and deactivation in cancers has been interrogated by studying infrequently occurring mutants of trimeric G-protein ?-subunits and GPCRs. Prior studies on members of a newly identified family of non-receptor guanine nucleotide exchange factors (GEFs), GIV/Girdin, Daple, NUCB1 and NUCB2 have revealed that GPCR-independent hyperactivation of trimeric G proteins can fuel metastatic progression in a variety of cancers. Here we report t...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2016
Band / Volume:
6
Seitenangaben Beitrag:
22112
Sprache:
eng
Volltext / DOI:
doi:10.1038/srep22112
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/26916336
Print-ISSN:
2045-2322
TUM Einrichtung:
Chirurgische Klinik und Poliklinik
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