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2015
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Document type:
Journal Article
Author(s):
Dieckmeyer, Michael; Ruschke, Stefan; Cordes, Christian; Yap, Samuel P; Kooijman, Hendrik; Hauner, Hans; Rummeny, Ernst J; Bauer, Jan S; Baum, Thomas; Karampinos, Dimitrios C
Title:
The need for T2 correction on MRS-based vertebral bone marrow fat quantification: implications for bone marrow fat fraction age dependence.
Abstract:
Vertebral bone marrow fat quantification using single-voxel MRS is confounded by overlapping water-fat peaks and the difference in T2 relaxation time between water and fat components. The purposes of the present study were: (i) to determine the proton density fat fraction (PDFF) of vertebral bone marrow using single-voxel multi-TE MRS, addressing these confounding effects; and (ii) to investigate the implications of these corrections with respect to the age dependence of the PDFF. Single-voxel MRS was performed in the L5 vertebral body of 86 subjects (54 women and 32 men). To reliably extract the water peak from the overlying fat peaks, the mean bone marrow fat spectrum was characterized based on the area of measurable fat peaks and an a priori knowledge of the chemical triglyceride structure. MRS measurements were performed at multiple TEs. The T2 -weighted fat fraction was calculated at each TE. In addition, a T2 correction was performed to obtain the PDFF and the T2 value of water (T2w ) was calculated. The implications of the T2 correction were investigated by studying the age dependence of the T2 -weighted fat fractions and the PDFF. Compared with the PDFF, all T2 -weighted fat fractions significantly overestimated the fat fraction. Compared with the age dependence of the PDFF, the age dependence of the T2 -weighted fat fraction showed an increased slope and intercept as TE increased for women and a strongly increased intercept as TE increased for men. For women, a negative association between the T2 value of bone marrow water and PDFF was found. Single-voxel MRS-based vertebral bone marrow fat quantification should be based on a multi-TE MRS measurement to minimize confounding effects on PDFF determination, and also to allow the simultaneous calculation of T2w , which might be considered as an additional parameter sensitive to the composition of the water compartment. Copyright © 2015 John Wiley & Sons, Ltd.
Journal title abbreviation:
NMR Biomed
Year:
2015
Journal volume:
28
Journal issue:
4
Pages contribution:
432-9
Language:
eng
Fulltext / DOI:
doi:10.1002/nbm.3267
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25683154
Print-ISSN:
0952-3480
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin; Fachgebiet Neuroradiologie (Prof. Zimmer)
BibTeX
Occurrences:
mediaTUM Gesamtbestand
Hochschulbibliographie
2015
Fakultäten
Medizin
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
mediaTUM Gesamtbestand
Hochschulbibliographie
2015
Fakultäten
Medizin
Institut für Radiologie
mediaTUM Gesamtbestand
Einrichtungen
Schools
TUM School of Medicine and Health
Departments
Clinical Medicine
Klinik für Ernährungsmedizin (Prof. Hauner)
2015
mediaTUM Gesamtbestand
Einrichtungen
Schools
TUM School of Medicine and Health
Departments
Clinical Medicine
Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)
Abteilung für Diagnostische und Interventionelle Neuroradiologie (Prof. Zimmer)
Professur für Neuroradiologie (Prof. Zimmer)
2015