User: Guest  Login
Title:

Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Journal Article
Author(s):
Szabó, András; Ludwig, Maren; Hegyi, Eszter; Szépeová, Renata; Witt, Heiko; Sahin-Tóth, Miklós
Abstract:
Human chymotrypsin C (CTRC) protects against pancreatitis by degrading trypsinogen and thereby curtailing harmful intra-pancreatic trypsinogen activation. Loss-of-function mutations in CTRC increase the risk for chronic pancreatitis. Here we describe functional analysis of eight previously uncharacterized natural CTRC variants tested for potential defects in secretion, proteolytic stability, and catalytic activity. We found that all variants were secreted from transfected cells normally, and non...     »
Journal title abbreviation:
J Biol Chem
Year:
2015
Journal volume:
290
Journal issue:
28
Pages contribution:
17282-92
Language:
eng
Fulltext / DOI:
doi:10.1074/jbc.M114.618439
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26013824
Print-ISSN:
0021-9258
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
 BibTeX